Dual Effect of High-Frequency Stimulation on Subthalamic Neuron Activity
نویسندگان
چکیده
منابع مشابه
Dual effect of high-frequency stimulation on subthalamic neuron activity.
Although it is well known that high-frequency stimulation (HFS) of the subthalamic nucleus (STN) alleviates the cardinal symptoms of Parkinson's disease, the underlying mechanisms are not fully understood. We investigated the effect of stimulation from low to high frequencies on rat STN neurons in naive and dopamine-depleted slices using whole-cell, current-clamp techniques and on-line artifact...
متن کاملInhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus.
Bilateral, high-frequency stimulation (HFS) of the subthalamic nucleus (STN) is the surgical therapy of choice for movement disability in advanced Parkinson's disease (PD), but this procedure evokes debilitating psychiatric effects, including depressed mood, of unknown neural origin. Here, we report the unexpected finding that HFS of the STN inhibits midbrain 5-hydroxytryptamine (5-HT) neurons ...
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BACKGROUND High-frequency stimulation of the subthalamic nucleus (STN) is a neurosurgical alternative to medical treatment in levodopa-responsive forms of Parkinson disease. The mechanism of action of STN stimulation remains controversial, although an inhibition of overactive STN neurons has been postulated. OBJECTIVE To determine the effects of high-frequency STN stimulation on the neuronal ...
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[High frequency stimulation of the subthalamic nucleus in Parkinson's disease].
has been a part of the CNRS unit of Professor Bernard Bioulac in Bordeaux since 2001, prior to which he was 'Chargé de Recherche' (CR1). For his PhD, which he obtained in 1993 in the field of neuroscience and pharmacology, Dr Benazzouz investigated a new therapeutical approach with high-frequency stimulation (HFS) of the subthalamic nucleus in a non-human primate model of Parkinson's disease (P...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2003
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.23-25-08743.2003